Zoxazolamine Explained

Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed.^{[1] [2]} It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity.^[3] One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. These drugs activate IK_Ca channels.^[4]

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 48–.
2. Book: Kar A . Medicinal Chemistry . 1 January 2005. New Age International. 978-81-224-1565-0. 185–.
3. Book: Lowry W . Forensic Toxicology: Controlled Substances and Dangerous Drugs. 6 December 2012. Springer Science & Business Media. 978-1-4684-3444-6. 166–.
4. Book: Offermanns S . Encyclopedia of Molecular Pharmacology. 14 August 2008. Springer Science & Business Media. 978-3-540-38916-3. 996–.