Zapotin Explained

Zapotin is a natural chemical compound, classified as a flavone, isolated from White sapote (Casimiroa edulis).^[1]

Several recent in vitro studies have shown that zapotin has potential anti-carcinogenic effects against isolated colon cancer cells.^{[2] [3]}

Notes and References

1. 10.1016/0040-4020(60)80001-4 . Constituents of Casimiroa edulis Llave et Lex.—VI 2′,5,6-Trimethoxyflavone, 2′,5,6,7-tetramethoxyflavone (zapotin) and 5-hydroxy-2′,6,7-trimethoxyflavone (zapotinin) . 1960 . Sondheimer . F . Tetrahedron . 9 . 3–4 . 139–144.
2. Murillo G . Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis . . 57 . 1 . 28–37 . 2007 . 17516860 . 10.1080/01635580701268097 . Hirschelman WH . Ito A . Moriarty . Robert M. . Kinghorn . A. Douglas . Pezzuto . John M. . Mehta . Rajendra G. . 20080099 .
3. Maiti A, Cuendet M, Kondratyuk T, Croy VL, Pezzuto JM, Cushman M . Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis . . . 50 . 2 . 350–5 . Jan 2007 . 17228877 . 2523270 . 10.1021/jm060915+.