Yfr1 Explained

Cyanobacterial functional RNA 1
Symbol:	Yfr1
Rfam:	RF01116
Rna Type:	Gene sRNA
Tax Domain:	Bacteria

Yfr1 is a Cyanobacterial functional RNA that was identified by a comparative genome based screen for RNAs in cyanobacteria.^[1] Further analysis has shown that the RNA is well conserved and highly expressed in cyanobacteria.^[2] and is required for growth under several stress condition^[3] Bioinformatics research combined with follow-up experiments have shown that Yfr1 inhibits the translation of the proteins PMM1119 and PMM1121 by an antisense interaction by base pairing at the ribosomal binding site.^[4]

See also

• Yfr2 RNA
• Cyano-S1 RNA motif
• Cyano-2 RNA motif

Notes and References

1. Axmann IM, Kensche P, Vogel J, Kohl S, Herzel H, Hess WR . Identification of cyanobacterial non-coding RNAs by comparative genome analysis. . Genome Biol . 6 . 9 . R73 . 2005 . 16168080 . 10.1186/gb-2005-6-9-r73 . 1242208 . free .
2. Voss B, Gierga G, Axmann IM, Hess WR . A motif-based search in bacterial genomes identifies the ortholog of the small RNA Yfr1 in all lineages of cyanobacteria. . BMC Genomics . 8. 375 . 2007 . 17941988 . 10.1186/1471-2164-8-375 . 2190773 . free .
3. Nakamura T, Naito K, Yokota N, Sugita C, Sugita M . A cyanobacterial non-coding RNA, Yfr1, is required for growth under multiple stress conditions . Plant Cell Physiol . 48 . 9 . 1309–1318 . 2007 . 17664182 . 10.1093/pcp/pcm098. free .
4. Richter AS, Schleberger C, Backofen R, Steglich C . Seed-based INTARNA prediction combined with GFP-reporter system identifies mRNA targets of the small RNA Yfr1 . Bioinformatics . 26 . 1 . 1–5 . 2010 . 19850757 . 10.1093/bioinformatics/btp609 . 2796815.