Xylulokinase Explained
| xylulokinase |
| Ec Number: | 2.7.1.17 |
| Cas Number: | 9030-58-4 |
| Go Code: | 0004856 |
| Width: | 270 |
In enzymology, a xylulokinase is an enzyme that catalyzes the chemical reaction
ATP + D-xylulose ADP + D-xylulose 5-phosphate
Thus, the two substrates of this enzyme are ATP and D-xylulose, whereas its two products are ADP and D-xylulose 5-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-xylulose 5-phosphotransferase. Other names in common use include xylulokinase (phosphorylating), and D-xylulokinase. This enzyme participates in pentose and glucuronate interconversions.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
Applications
Hydrogen production
In 2014 a low-temperature 50C, atmospheric-pressure enzyme-driven process to convert xylose into hydrogen with nearly 100% of the theoretical yield was announced. The process employs 13 enzymes, including xylulokinase.[1] [2]
Further reading
- Bunker RD, Bulloch EM, Dickson JM, Loomes KM, Baker EN . Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism . The Journal of Biological Chemistry . 288 . 3 . 1643–52 . January 2013 . 23179721 . 3548474 . 10.1074/jbc.m112.427997 . free .
- Hickman J . Ashwell G . 1958 . Purification and properties of D-xylulokinase in liver . J. Biol. Chem. . 232 . 2 . 737 - 748 . 10.1016/S0021-9258(19)77394-3 . 13549459 . free .
- Book: Simpson FJ . 1966 . D-Xylulokinase . Methods Enzymol. . 9 . 454 - 458 . 10.1016/0076-6879(66)09093-1. 978-0-12-181809-8 .
- Slein MW . 1955 . Xylose isomerase from Pasteurella pestis, strain A-1122 . J. Am. Chem. Soc. . 77 . 1663 - 1667 . 10.1021/ja01611a074 . 6 .
- Stumpf PK, Horecker BL . The role of xylulose 5-phosphate in xylose metabolism of Lactobacillus pentosus . The Journal of Biological Chemistry . 218 . 2 . 753–68 . February 1956 . 10.1016/S0021-9258(18)65840-5 . 13295228 . free .
Notes and References
- Virginia Tech team develops process for high-yield production of hydrogen from xylose under mild conditions . 10.1002/anie.201300766. Green Car Congress . 2013-04-03 . 23512726 . 2014-01-22. Martín Del Campo . J. S. . Rollin . J. . Myung . S. . Chun . Y. . Chandrayan . S. . Patiño . R. . Adams . M. W. . Zhang . Y. H. . Angewandte Chemie International Edition in English . 52 . 17 . 4587–90 .
- Martín del Campo JS, Rollin J, Myung S, Chun Y, Chandrayan S, Patiño R, Adams MW, Zhang YH . High-yield production of dihydrogen from xylose by using a synthetic enzyme cascade in a cell-free system . Angewandte Chemie . 52 . 17 . 4587–90 . April 2013 . 23512726 . 10.1002/anie.201300766 .
