| Verifiedfields: | changed |
| Watchedfields: | changed |
| Verifiedrevid: | 459852622 |
| Iupac Name: | 2-[(4-''tert''-butyl-2,6-dimethylphenyl)methyl]- 4,5-dihydro-1H-imidazole |
| Width: | 150px |
| Pronounce: | |
| Tradename: | Otrivin, Otrivine, others |
| Dailymedid: | Xylometazoline |
| Pregnancy Category: | C |
| Legal Status: | OTC |
| Dependency Liability: | Moderate[1] |
| Routes Of Administration: | intranasal (spray or drops) |
| Class: | α1 and α2 Adrenergic receptor agonist, Decongestant |
| Elimination Half-Life: | >10 seconds |
| Excretion: | Urinary |
| Cas Number: | 526-36-3 |
| Atc Prefix: | R01 |
| Atc Suffix: | AA07 |
| Pubchem: | 5709 |
| Iuphar Ligand: | 517 |
| Drugbank: | DB06694 |
| Chemspiderid: | 5507 |
| Unii: | WPY40FTH8K |
| Kegg: | D08684 |
| Chembl: | 312448 |
| C: | 16 |
| H: | 24 |
| N: | 2 |
| Smiles: | N\1=C(\NCC/1)Cc2c(cc(cc2C)C(C)(C)C)C |
| Stdinchi: | 1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18) |
| Stdinchikey: | HUCJFAOMUPXHDK-UHFFFAOYSA-N |
Xylometazoline, also spelled xylomethazoline, is a drug used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis.[2] Use is not recommended for more than seven days. Use is also not recommended in those less than three months of age and some say not less than 6 years of age. It is used directly in the nose as a spray or drops.
Side effects include trouble sleeping, irritation of the nose, nausea, nosebleed (3%), period pain (10%) and headache (3%).[3] [2] Long term use (> 10 days) is not recommended due to a rhinitis medicamentosa when stopped.[3] Use is not recommended during pregnancy.[2] Xylometazoline is in the decongestant and alpha-adrenergic agonist families of medication.[4] [5]
One study classified it with selectivity ratios in alpha 2 adrenergic receptors of 151 for a2A vs a2B, 4.5 a2A vs a2C, and 33.9 a2B vs a2C. Making it a highly selective a2A agonist.[6]
Xylometazoline was patented in 1956 and came into medical use in 1959.[7] [8] It is on the World Health Organization's List of Essential Medicines.[9] [10] Xylometazoline is available as a generic medication.[11]
The drug works by stimulating adrenergic receptors on the lamina propria of blood vessels in the nose. The decongestant effect is due to constriction of large veins in the nose which swell up during the inflammation of any infection or allergy of the nose. The smaller arteries are also constricted and this causes the colour of the nasal epithelium to be visibly paler after dosage.
Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α1 and α2 adrenergic receptors[12] in the nasal mucosa. Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems.
Extended usage of xylometazoline can result in decreased effectiveness or a buildup of tolerance against the drug.[13] The number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa, commonly referred to as rebound congestion. Moreover, long-term overdosing can cause degenerative changes in nasal mucous membranes that pose another health problem.
The most common name for over-the-counter products containing xylometazoline internationally is "Otrivin" (used in Australia,[14] Canada, Estonia, Finland, Greece, Hungary, India,[15] Israel, Jordan, Netherlands, New Zealand, Norway, Poland, South Africa, Sweden, Vietnam, Hong Kong), "Otrivine" (United Kingdom, Ireland, Turkey, Belgium), or "Otriven" (Germany). A product marketed as "Otrivin Oxy" contains oxymetazoline instead of xylometazoline.
Other product names used include Antazol (Square, in Bangladesh), Xylomet (Opsonin, Bangladesh), Cirovin, Klarigen (in Denmark), Nasolin, Neo-Rinoleina, Novorin, Olynth, Otrinoz, Galazolin[16] (Russia, Ukraine, Belarus), Nasomist-X, Otrix, Rhinoset, Zenfresh, Naphthyzinium, Xymelyn (in Latvia), Sinutab Nasal Spray, Snup akut, Sudafed, Xylo-COMOD, Xylolin (in the United Arab Emirates), Xylovit, Olynth (in Serbia, the Czech Republic and Slovakia), Meralys (in Croatia) Xynosine (in Pakistan, Afghanistan, Kyrgyzstan and Kazakhstan), Xymelin, Zymelin, Xylostar, Xylorin (in Poland), Nasobol, Xylo Mepha and others (Switzerland), Decozal (in Jordan), Nasic, Orinox (Romania), Narhimed (Italy), nasa Rhinathiol (Belgium) and Zolinol,[17] Nasorhinathiol[18] and Vibrocil[19] (Portugal].
As of 2021, a number of consumer products containing xylometazoline are marketed in the United States.[20]
The standard adult solution strength is 0.1% w/v xylometazoline (or 1 mg per 1 mL solution), and the dose for children under 12 is usually 0.05% (0.5 mg/mL).[21]