Xanthosine monophosphate explained

Xanthosine monophosphate (xanthylate) is an intermediate in purine metabolism.^[1] It is a ribonucleoside monophosphate. It is formed from IMP via the action of IMP dehydrogenase, and it forms GMP via the action of GMP synthase. Also, XMP can be released from XTP by enzyme deoxyribonucleoside triphosphate pyrophosphohydrolase containing (d)XTPase activity.^[2]

It is abbreviated XMP.^[3]

See also

• Xanthosine

Further reading

• 19623361. 2009. Sigel. H. Operschall. BP. Griesser. R. Xanthosine 5'-monophosphate (XMP). Acid-base and metal ion-binding properties of a chameleon-like nucleotide. 38. 8. 2465–94. 10.1039/b902181g. Chemical Society Reviews. 205726340 . https://web.archive.org/web/20200101060055/http://pdfs.semanticscholar.org/e8ab/b310691cc11a918c7769e0d38e42232ad5b6.pdf. dead. 2020-01-01.
• 20087997. 2010. Egli. M. Pallan. PS. Crystallographic studies of chemically modified nucleic acids: A backward glance. 7. 1. 60–89. 10.1002/cbdv.200900177. 2905155. Chemistry & Biodiversity.

Notes and References

1. Book: McMurry, John. Organic chemistry: a biological approach. 26 March 2012. 2007. Cengage Learning. 9780495015253. 1007–.
2. Davies O, Mendes P, Smallbone K, Malys N . Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism . BMB Reports . 45 . 4 . 259–64 . 2012 . 22531138. 10.5483/BMBRep.2012.45.4.259. free .
3. Gogia . S. . Balaram . H. . Puranik . M. . Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate. . Biochemistry . 50 . 19 . 4184–93 . May 2011 . 10.1021/bi102039b . 21486037 .