Wogonin Explained

Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.[1]

The glycosides of wogonin are known as wogonosides. For example, oroxindin is a wogonin glucuronide isolated from Oroxylum indicum.[2] It is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement.

Pharmacology

Wogonin has been found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines. Preliminary in vitro studies have shown pharmacological effects that indicate wogonin may have anti-tumor properties.[3] [4] Wogonin has also been found to possess anticonvulsant effects.[5] It acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an binding affinity of Ki 0.92μM and an IC50 value of 1.26μM which is about 100x less potent than diazepam (IC50 value of 0.012μM). The LD50 of pure Wogonin in mice is 3.9 grams per kilogram of body weight suggesting low toxicity [6]

Notes and References

  1. Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong JT, Xue H . Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi . Biochem. Pharmacol. . 64 . 9 . 1415–24 . 2002 . 12392823 . 10.1016/s0006-2952(02)01347-3.
  2. Oroxindin—A new flavone glucuronide from Oroxylum indicum . Proceedings of the Indian Academy of Sciences - Chemical Sciences . 88 . 323–327 . October 1979 . 10.1007/BF02844710 . Ramachandran Nair AG . Joshi BS . 90414405 .
  3. Lin CC, Kuo CL, Lee MH, Lai KC, Lin JP, Yang JS, Yu CS, Lu CC, Chiang JH, Chueh FS, Chung JG . Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways . International Journal of Oncology . 2011 . 39 . 1 . 217–224 . 21573491 . 10.3892/ijo.2011.1027. free .
  4. Gao J, Morgan WA, Sanchez-Medina A, Corcoran O . The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells . Toxicology and Applied Pharmacology . 2011 . 254 . 3 . 221–8 . 10.1016/j.taap.2011.03.016 . 21457722.
  5. Park HG, Yoon SY, Choi JY, Lee GS, Choi JH, Shin CY, Son KH, Lee YS, Kim WK, Ryu JH, Ko KH, Cheong JH . Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis . European Journal of Pharmacology . 574 . 2–3 . 112–9 . 2007 . 17692312 . 10.1016/j.ejphar.2007.07.011 .
  6. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi . 10.1016/S0006-2952(02)01347-3 . 2002 . Hui . Kwok Min . Huen . Michael S.Y. . Wang . Hong Yan . Zheng . Hui . Sigel . Erwin . Baur . Roland . Ren . Hong . Li . Zhi Wang . Wong . J.Tze-Fei . Xue . Hong . Biochemical Pharmacology . 64 . 9 . 1415–1424 . 12392823 .

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