WNT2 explained

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.^{[1] [2]}

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.^[1]

Further reading

• Katoh M . WNT2 and human gastrointestinal cancer (review). . Int. J. Mol. Med. . 12 . 5 . 811–6 . 2003 . 14533014 . 10.3892/ijmm.12.5.811.
• Li J, Nguyen L, Gleason C, etal . Lack of evidence for an association between WNT2 and RELN polymorphisms and autism. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 126B . 1 . 51–7 . 2004 . 15048648 . 10.1002/ajmg.b.20122 . 19378694 .
• Pu P, Zhang Z, Kang C, etal . Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth. . Cancer Gene Ther. . 16 . 4 . 351–61 . 2009 . 18949017 . 10.1038/cgt.2008.78 . free .
• Kodo K, Nishizawa T, Furutani M, etal . GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. . Proc. Natl. Acad. Sci. U.S.A. . 106 . 33 . 13933–8 . 2009 . 19666519 . 10.1073/pnas.0904744106 . 2728998 . 2009PNAS..10613933K . free .
• Clément G, Braunschweig R, Pasquier N . Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. . Oncogene . 25 . 21 . 3084–92 . 2006 . 16407829 . 10.1038/sj.onc.1209338 . etal. free .
• Park JK, Song JH, He TC, etal . Overexpression of Wnt-2 in colorectal cancers. . Neoplasma . 56 . 2 . 119–23 . 2009 . 19239325 . 10.4149/neo_2009_02_119 . free .
• Flahaut M, Meier R, Coulon A, etal . The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway. . Oncogene . 28 . 23 . 2245–56 . 2009 . 19421142 . 10.1038/onc.2009.80 . 205531490 . free .
• Liu ZL, Li Y, Kong QY, etal . Immunohistochemical profiling of Wnt, NF-kappaB, Stat3 and Notch signaling in human epidermal tumors. . J. Dermatol. Sci. . 52 . 2 . 133–6 . 2008 . 18703315 . 10.1016/j.jdermsci.2008.06.011 .
• Kloth JN, Fleuren GJ, Oosting J, etal . Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines. . Carcinogenesis . 26 . 9 . 1493–502 . 2005 . 15878915 . 10.1093/carcin/bgi110 . free .
• Mazieres J, You L, He B, etal . Wnt2 as a new therapeutic target in malignant pleural mesothelioma. . Int. J. Cancer . 117 . 2 . 326–32 . 2005 . 15900580 . 10.1002/ijc.21160 . 23153113 . free .
• Wang HX, Tekpetey FR, Kidder GM . Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. . Mol. Hum. Reprod. . 15 . 1 . 11–7 . 2009 . 19038973 . 10.1093/molehr/gan070 . free .
• Han JC, Zhang KL, Chen XY, etal . Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling. . APMIS . 115 . 12 . 1331–43 . 2007 . 18184402 . 10.1111/j.1600-0643.2007.00695.x . 42263784 .
• Mary Pat Moyer . Planutis K, Planutiene M, Moyer MP, etal . Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. . BMC Cell Biol. . 8 . 12 . 2007 . 17386109 . 10.1186/1471-2121-8-12 . 1847812 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Cheng XX, Wang ZC, Chen XY, etal . Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin. . Clin. Exp. Metastasis . 22 . 1 . 85–93 . 2005 . 16132582 . 10.1007/s10585-005-4578-8 . 20775755 .
• Shi Y, He B, Kuchenbecker KM, etal . Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. . Int. J. Cancer . 121 . 6 . 1175–81 . 2007 . 17534895 . 10.1002/ijc.22848 . 23180009 . free .
• Cheng XX, Wang ZC, Chen XY, etal . Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination. . Cancer Lett. . 223 . 2 . 339–47 . 2005 . 15896469 . 10.1016/j.canlet.2004.11.013 .
• Ma XR, Edmund Sim UH, Pauline B, etal . Overexpression of WNT2 and TSG101 genes in colorectal carcinoma. . Tropical Biomedicine . 25 . 1 . 46–57 . 2008 . 18600204 .
• de Krom M, Staal WG, Ophoff RA, etal . A common variant in DRD3 receptor is associated with autism spectrum disorder. . Biol. Psychiatry . 65 . 7 . 625–30 . 2009 . 19058789 . 10.1016/j.biopsych.2008.09.035 . 11545813 .

Notes and References

1. Web site: Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2.
2. Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS . Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless . EMBO J. . 7 . 6 . 1743–8 . June 1988 . 2971536 . 457162 . 10.1002/j.1460-2075.1988.tb03003.x .