| Prefoldin subunit 3 | |
| Hgncid: | 12662 |
| Symbol: | VBP1 |
| Entrezgene: | 7411 |
| Omim: | 300133 |
| Refseq: | NM_003372 |
| Uniprot: | P61758 |
| Chromosome: | X |
| Arm: | q |
| Band: | 28 |
Prefoldin subunit 3 (VBP-1),[1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[3]
VBP-1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[3] and is a member of the prefoldin-α subunit family.[4] It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm.[4] The VBP1 gene is located at Xq28.[5] Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans.[3]