Vicenistatin Explained

Vicenistatin is a macrolactam antibiotic synthesized by Streptomyces halstedii HC34. It was originally isolated from this bacterium in 1993.[1] It includes the unusual starter unit methylaspartate.[2]

Notes and References

  1. Shindo K, Kamishohara M, Odagawa A, Matsuoka M, Kawai H . Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic . The Journal of Antibiotics . 46 . 7 . 1076–81 . July 1993 . 8360102 . 10.7164/antibiotics.46.1076 . free .
  2. Ogasawara Y, Kakinuma K, Eguchi T . Involvement of glutamate mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin . The Journal of Antibiotics . 58 . 7 . 468–72 . July 2005 . 16161486 . 10.1038/ja.2005.62 . free .

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