Vibriobactin Explained

Vibriobactin is a catechol siderophore that helps the microbial system to acquire iron. It was first isolated from Vibrio cholerae.[1]

Structure and biosynthesis

The components of vibriobactin are three 2,3-dihydroxybenzoic acid (DHB), two threonine (Thr), and one norspermidine (NSPD). DHB is synthesized from chorismic acid by a series of enzymes: VibA, VibB, and VibC. DHB is linked to NSPD by VibE, VibB and VibH in order and forms DHB-NSPD.[2] On the other hand, DHB performs condensation and cyclization with Thr by VibE, VibB, and VibF to form the heterocyclic molecule linked on VibF: DHB-Thr-VibF. DHB-NSPD and DHB-Thr-VibF are then put together by VibF to form vibriobactin.[3]

Notes and References

  1. Griffiths. Gary L.. Sigel. Suzanne P.. Payne. Shelley M.. Neilands. J. B.. Vibriobactin, a Siderophore from Vibrio cholerae. The Journal of Biological Chemistry. 1984. 259. 1. 383–385. 10.1016/S0021-9258(17)43671-4. 6706943. free.
  2. Keating. Thomas A.. Marshall. C. Gary. Walsh. Christopher T.. Vibriobactin Biosynthesis in Vibrio cholerae: VibH Is an Amide Synthase Homologous to Nonribosomal Peptide Synthetase Condensation Domains. Biochemistry. 2000. 39. 50. 15514. 10.1021/bi001651a. 11112537.
  3. Marshall. C. Gary. Burkart. Michael D.. Keating. Thomas A.. Walsh. Christopher T.. Heterocycle Formation in Vibriobactin Biosynthesis: Alternative Substrate Utilization and Identification of a Condensed Intermediate.. Biochemistry. 2001. 40. 35. 10656. 10.1021/bi010937s. 11524010.

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