Vesicular inhibitory amino acid transporter explained

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.^[1]

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.

See also

• Solute carrier family

Further reading

• McIntire SL, Reimer RJ, Schuske K, etal . Identification and characterization of the vesicular GABA transporter . Nature . 389 . 6653 . 870–6 . 1997 . 9349821 . 10.1038/39908 . 4404823 .
• Kleiderlein JJ, Nisson PE, Jessee J, etal . CCG repeats in cDNAs from human brain . Hum. Genet. . 103 . 6 . 666–73 . 1999 . 9921901 . 10.1007/s004390050889 . 23696667 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Chessler SD, Simonson WT, Sweet IR, Hammerle LP . Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets . Diabetes . 51 . 6 . 1763–71 . 2002 . 12031963 . 10.2337/diabetes.51.6.1763 . free .
• Jellali A, Stussi-Garaud C, Gasnier B, etal . Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina . J. Comp. Neurol. . 449 . 1 . 76–87 . 2002 . 12115694 . 10.1002/cne.10272 . 27646744 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Geigerseder C, Doepner R, Thalhammer A, etal . Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors . Neuroendocrinology . 77 . 5 . 314–23 . 2003 . 12806177 . 10.1159/000070897 . 7652352 . 11336/36231 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Web site: Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1.