Vesicle-fusing ATPase explained

Vesicle-fusing ATPase
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In enzymology, a vesicle-fusing ATPase is an enzyme that catalyzes the chemical reaction

ATP + H₂O

\rightleftharpoons ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (vesicle-fusing).

References

• Confalonieri F, Duguet M . 1995 . A 200-amino acid ATPase module in search of a basic function . BioEssays . 17 . 639 - 50 . 7646486 . 10.1002/bies.950170710 . 7 .
• Orii T, Kondo N, Osumi T, Fujiki Y . 1998 . Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders . Hum. Mol. Genet. . 7 . 2089 - 94 . 9817926 . 10.1093/hmg/7.13.2089 . 13 . free .
• Babst M, Wendland B, Estepa EJ, Emr SD . 1998 . The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function . EMBO J. . 17 . 2982 - 93 . 9606181 . 10.1093/emboj/17.11.2982 . 11 . 1170638 .