Very-long-chain enoyl-CoA reductase explained

Very-long-chain enoyl-CoA reductase
Ec Number:	1.3.1.93

Very-long-chain enoyl-CoA reductase (TSC13 (gene name), CER10 (gene)) is an enzyme with systematic name very-long-chain acyl-CoA:NADP⁺ oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

a very-long-chain acyl-CoA + NADP⁺

\rightleftharpoons a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H⁺

This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA.

Notes and References

1. Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T . Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae . Molecular and Cellular Biology . 21 . 1 . 109–25 . January 2001 . 11113186 . 88785 . 10.1128/MCB.21.1.109-125.2001 .
2. Gable K, Garton S, Napier JA, Dunn TM . Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system . Journal of Experimental Botany . 55 . 396 . 543–5 . February 2004 . 14673020 . 10.1093/jxb/erh061 . free .
3. Kvam E, Gable K, Dunn TM, Goldfarb DS . Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles . Molecular Biology of the Cell . 16 . 9 . 3987–98 . September 2005 . 15958487 . 1196313 . 10.1091/mbc.E05-04-0290 .
4. Zheng H, Rowland O, Kunst L . Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis . The Plant Cell . 17 . 5 . 1467–81 . May 2005 . 15829606 . 1091768 . 10.1105/tpc.104.030155 .