Very-long-chain acyl-CoA dehydrogenase explained
| Very-long-chain acyl-CoA dehydrogenase |
| Ec Number: | 1.3.8.9 |
| Width: | 270 |
Very-long-chain acyl-CoA dehydrogenase (ACADVL (gene).) is an enzyme with systematic name very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.[1] [2] [3] This enzyme catalyses the following chemical reaction
a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
This enzyme contains FAD as prosthetic group.
Notes and References
- Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T . Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase . The Journal of Biological Chemistry . 267 . 2 . 1027–33 . January 1992 . 10.1016/S0021-9258(18)48390-1 . 1730632 . free .
- Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T . Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients . The Journal of Clinical Investigation . 95 . 6 . 2465–73 . June 1995 . 7769092 . 295925 . 10.1172/JCI117947 .
- McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ . Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase . The Journal of Biological Chemistry . 283 . 14 . 9435–43 . April 2008 . 18227065 . 2431035 . 10.1074/jbc.M709135200 . free .
