Very-long-chain 3-oxoacyl-CoA reductase explained

Very-long-chain 3-oxoacyl-CoA reductase
Ec Number:	1.1.1.330

Very-long-chain 3-oxoacyl-CoA reductase (very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP⁺ oxidoreductase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP⁺

\rightleftharpoons a very-long-chain 3-oxoacyl-CoA + NADPH + H⁺

This microsomal complex extends palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.

Notes and References

1. Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA . A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase . The Journal of Biological Chemistry . 277 . 13 . 11481–8 . March 2002 . 11792704 . 10.1074/jbc.M111441200 . free .
2. Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM . The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase . The Journal of Biological Chemistry . 277 . 38 . 35440–9 . September 2002 . 12087109 . 10.1074/jbc.M205620200 . free .
3. Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L . Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase . Plant Physiology . 150 . 3 . 1174–91 . July 2009 . 19439572 . 2705042 . 10.1104/pp.109.137497 .