| vasoactive intestinal peptide receptor 1 | |
| Hgncid: | 12694 |
| Symbol: | VIPR1 |
| Altsymbols: | RDC1, HVR1, VAPC1 |
| Entrezgene: | 7433 |
| Omim: | 192321 |
| Refseq: | NM_004624 |
| Uniprot: | P32241 |
| Chromosome: | 3 |
| Arm: | p |
| Band: | 22 |
| vasoactive intestinal peptide receptor 2 | |
| Hgncid: | 12695 |
| Symbol: | VIPR2 |
| Altsymbols: | VPAC2 |
| Entrezgene: | 7434 |
| Omim: | 601970 |
| Refseq: | NM_003382 |
| Uniprot: | P41587 |
| Chromosome: | 7 |
| Arm: | q |
| Band: | 36.3 |
| adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | |
| Hgncid: | 242 |
| Symbol: | ADCYAP1R1 |
| Altsymbols: | PACAPR |
| Entrezgene: | 117 |
| Omim: | 102981 |
| Refseq: | NM_001118 |
| Uniprot: | P41586 |
| Chromosome: | 7 |
| Arm: | p |
| Band: | 14 |
There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1] [2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.
VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.
VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]