Vasicine Explained

Vasicine (peganine) is a quinazoline alkaloid. It is found in Justicia adhatoda, after which it is named. It is additionally found in Peganum harmala.[1]

Vasicine has been compared to theophylline both in vitro and in vivo.[2] It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro.[3] Both alkaloids are also respiratory stimulants.[3] Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids.[3] [4] Vasicine is reported to have a uterine stimulant effect.[4]

Notes and References

  1. Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J . Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids . Pharmacogn Rev . 7 . 14 . 199–212 . July 2013 . 24347928 . 3841998 . 10.4103/0973-7847.120524 . free .
  2. Nepali. Kunal. Sharma. Sahil. Ojha. Ritu. Dhar. Kanaya Lal. Vasicine and structurally related quinazolines. Medicinal Chemistry Research. 22. 1. 2012. 1–15. 1054-2523. 10.1007/s00044-012-0002-5. 253636554 .
  3. Avula . B. . Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis . Die Pharmazie . 63 . 1 . 2008 . 20–22 . 10.1691/ph.2008.7175 . 18271297 . etal.
  4. Rajani. M. Soni. S. Anandjiwala. Sheetal. Patel. G. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian Journal of Pharmaceutical Sciences. 70. 1. 2008. 36–42. 0250-474X. 10.4103/0250-474X.40329. 20390078. 2852058. free.

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