Kinase insert domain receptor explained

Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.^[1]

Interactions

Kinase insert domain receptor has been shown to interact with SHC2,^[2] Annexin A5^[3] and SHC1.^{[4] [5]}

See also

• Cluster of differentiation
• VEGF receptors

Further reading

• Holmes K, Roberts OL, Thomas AM, Cross MJ . Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition . Cellular Signalling . 19 . 10 . 2003–12 . October 2007 . 17658244 . 10.1016/j.cellsig.2007.05.013 .
• Petrova TV, Makinen T, Alitalo K . Signaling via vascular endothelial growth factor receptors . Experimental Cell Research . 253 . 1 . 117–30 . November 1999 . 10579917 . 10.1006/excr.1999.4707 .
• Wang J, Fu X, Jiang C, Yu L, Wang M, Han W, Liu L, Wang J . Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia . Behavioural Brain Research . 265 . 171–80 . May 2014 . 24589546 . 4000455 . 10.1016/j.bbr.2014.02.033 .
• Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M . Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction . Annals of the New York Academy of Sciences . 902 . 1 . 201–5; discussion 205–7 . May 2000 . 10865839 . 10.1111/j.1749-6632.2000.tb06314.x . 2000NYASA.902..201S . 11488629 .
• Zachary I, Gliki G . Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family . Cardiovascular Research . 49 . 3 . 568–81 . February 2001 . 11166270 . 10.1016/S0008-6363(00)00268-6 . free .
• Vené R, Benelli R, Noonan DM, Albini A . HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis . Clinical & Experimental Metastasis . 18 . 7 . 533–8 . 2001 . 11688957 . 10.1023/A:1011991906685 . 24787929 .
• Lenton K . VEGFR-2 (KDR/Flk-1) . Journal of Biological Regulators and Homeostatic Agents . 16 . 3 . 227–32 . 2003 . 12456025 .
• Matsumoto T, Mugishima H . Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis . Journal of Atherosclerosis and Thrombosis . 13 . 3 . 130–5 . June 2006 . 16835467 . 10.5551/jat.13.130 . free .

Notes and References

1. Glubb DM, Cerri E, Giese A, Zhang W, Mirza O, Thompson EE, Chen P, Das S, Jassem J, Rzyman W, Lingen MW, Salgia R, Hirsch FR, Dziadziuszko R, Ballmer-Hofer K, Innocenti F . Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer . Clinical Cancer Research . 17 . 16 . 5257–67 . August 2011 . 21712447 . 3156871 . 10.1158/1078-0432.CCR-11-0379 .
2. Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA . The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells . The Biochemical Journal . 347 . Pt 2 . 501–9 . April 2000 . 10749680 . 1220983 . 10.1042/0264-6021:3470501 .
3. Wen Y, Edelman JL, Kang T, Sachs G . Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1 . Biochemical and Biophysical Research Communications . 258 . 3 . 713–21 . May 1999 . 10329451 . 10.1006/bbrc.1999.0678 .
4. Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M, Lanfrancone L, Dejana E . Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling . Arteriosclerosis, Thrombosis, and Vascular Biology . 22 . 4 . 617–22 . April 2002 . 11950700 . 10.1161/01.ATV.0000012268.84961.AD . free .
5. D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI . 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells . Molecular Endocrinology . 13 . 5 . 692–704 . May 1999 . 10319320 . 10.1210/mend.13.5.0280 . free .