Vapreotide Explained

Vapreotide (Sanvar) is a synthetic somatostatin analog. It is used in the treatment of esophageal variceal bleeding[1] [2] in patients with cirrhotic liver disease and AIDS-related diarrhea.

It is an 8 residue peptide with sequence H-D-Phe-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Trp-NH2.

Notes and References

  1. Calès P . Vapreotide acetate for the treatment of esophageal variceal bleeding . Expert Review of Gastroenterology & Hepatology . 2 . 2 . 185–92 . April 2008 . 19072353 . 10.1586/17474124.2.2.185 . 2681639 .
  2. Fortune BE, Jackson J, Leonard J, Trotter JF . Vapreotide: a somatostatin analog for the treatment of acute variceal bleeding . Expert Opinion on Pharmacotherapy . 10 . 14 . 2337–42 . October 2009 . 19708854 . 10.1517/14656560903207019 . 24475861 .

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