Vanillyl-alcohol oxidase explained

vanillyl-alcohol oxidase
Ec Number:	1.1.3.38
Cas Number:	143929-24-2
Go Code:	0018465
Width:	270

In enzymology, a vanillyl-alcohol oxidase is an enzyme that catalyzes the chemical reaction

+ O₂

\rightleftharpoons + H₂O₂

Thus, the two substrates of this enzyme are vanillyl alcohol and O₂, whereas its two products are vanillin and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is vanillyl alcohol:oxygen oxidoreductase. This enzyme is also called 4-hydroxy-2-methoxybenzyl alcohol oxidase. This enzyme participates in 2,4-dichlorobenzoate degradation. It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .

References

• de Jong E, van Berkel WJ, van der Zwan RP, de Bont JA . 1992 . Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD . Eur. J. Biochem. . 208 . 651 - 657 . 1396672 . 10.1111/j.1432-1033.1992.tb17231.x . 3 . free .
• Fraaije MW, Veeger C, van Berkel WJ . 1995 . Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols . Eur. J. Biochem. . 234 . 271 - 277 . 8529652 . 10.1111/j.1432-1033.1995.271_c.x . 1 . free .