Amlodipine/valsartan explained
| Verifiedrevid: | 396294114 |
| Type: | combo |
| Component1: | Amlodipine |
| Class1: | Calcium channel blocker |
| Component2: | Valsartan |
| Class2: | Angiotensin II receptor antagonist |
| Tradename: | Exforge |
| Licence Eu: | yes |
| Dailymedid: | Amlodipine_and_valsartan |
| Pregnancy Au: | D |
| Pregnancy Au Comment: | [1] |
| Routes Of Administration: | By mouth |
| Atc Prefix: | C09 |
| Atc Suffix: | DB01 |
| Legal Us: | Rx-only |
| Legal Us Comment: | [2] |
| Legal Eu: | Rx-only |
| Index2 Label: | with HCTZ |
| Cas Number: | 1190398-97-0 |
| Pubchem: | 11354874 |
| Chemspiderid: | 13092186 |
| Kegg: | D09745 |
| Kegg2: | D10286 |
Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine, as the besilate, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin II receptor antagonist.[3] This combination is usually well tolerated and effective for the reduction of blood pressure.[4]
The combination was approved for medical use in the United States in June 2007.[5]
The combination is also available with included hydrochlorothiazide (Exforge HCT), for people who need a three-drug regimen to manage their blood pressure.[6] [7] It was approved for medical use in the United States in April 2009.[8]
External links
Notes and References
- Web site: Amlodipine / valsartan (Exforge) Use During Pregnancy . Drugs.com . 11 July 2019 . 13 February 2020.
- Web site: Exforge- amlodipine besylate and valsartan tablet, film coated . DailyMed . 12 June 2019 . 12 February 2020.
- Web site: Valsartan Monograph for Professionals . Drugs.com . American Society of Health-System Pharmacists . 3 March 2019.
- Eckert S, Freytag SB, Müller A, Klebs SH . Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors . Blood Pressure . 22 . sup1 . 11–21 . September 2013 . 23713686 . 10.3109/08037051.2013.793891 . 25814898 .
- Web site: Drug Approval Package: Exforge (amlodipine and valsartan) NDA #021990 . U.S. Food and Drug Administration (FDA) . 3 October 2008 . 19 September 2021.
- Web site: Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated . DailyMed . 12 February 2020.
- Web site: Amlodipine, Valsartan, and Hydrochlorothiazide . Drugs.com .
- Web site: Drug Approval Package: Exforge HCT (Amlodipine, Valsartan, Hydrochlorothiazide) Tablets NDA #022314 . U.S. Food and Drug Administration (FDA) . 2 September 2009 . 19 September 2021 .
