Valine dehydrogenase (NADP+) explained
| valine dehydrogenase (NADP) |
| Ec Number: | 1.4.1.8 |
| Cas Number: | 37255-39-3 |
| Go Code: | 0050391 |
In enzymology, a valine dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction
L-valine + H2O + NADP+
3-methyl-2-oxobutanoate + NH
3 + NADPH + H
+The 3 substrates of this enzyme are L-valine, H2O, and NADP+, whereas its 4 products are 3-methyl-2-oxobutanoate, NH3, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-valine:NADP+ oxidoreductase (deaminating). Other names in common use include valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), and valine dehydrogenase (NADP+).
References
- Kagan ZS, Kretovich WL, Polyakov WA . 1966 . Biosynthesis of valine by reductive amination of its keto analogue in plants . Enzymologia . 30 . 343 - 66 . 6005410 . 6 .
- Kagan ZS, Poliakov VA, Kretovich VL . 1968 . [Soluble valine dehydrogenase from roots of plant seedings] . Biokhimiia . 33 . 89 - 96 . 4385962 . 1 .
- Kagan ZS, Poliakov VA, Kretovich VL . 1969 . [Purification and properties of valine dehydrogenase] . Biokhimiia . 34 . 59 - 65 . 4389825 . 1 .
- Behal V . 1988 . Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens . J. Bacteriol. . 170 . 5192 - 6 . 3182727 . Vancura . A . Volc . J . Neuzil . J . Flieger . M . Basarová . G . Gabriela Basařová . Bĕhal . V . 11 . 211589 . 10.1128/jb.170.11.5192-5196.1988.
