Valine dehydrogenase (NAD+) explained

Valine dehydrogenase (NAD^+)
Ec Number:	1.4.1.23

Valine dehydrogenase (NAD⁺) is an enzyme with systematic name L-valine:NAD⁺ oxidoreductase (deaminating).^{[1] [2]} This enzyme catalyses the following chemical reaction

L-valine + H₂O + NAD⁺

\rightleftharpoons 3-methyl-2-oxobutanoate + NH₃ + NADH + H⁺

The enzyme from Streptomyces spp. has no activity with NADP⁺.

See also

• Valine dehydrogenase (NADP+)

Notes and References

1. Vancurová I, Vancura A, Volc J, Neuzil J, Flieger M, Basarová G, Bĕhal V . Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens . Journal of Bacteriology . 170 . 11 . 5192–6 . November 1988 . 3182727 . 211589 . 10.1128/jb.170.11.5192-5196.1988 .
2. Navarrete RM, Vara JA, Hutchinson CR . Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2) . Journal of General Microbiology . 136 . 2 . 273–81 . February 1990 . 2324704 . 10.1099/00221287-136-2-273 . free .