Utidelone Explained

Drug Name:	Utidelone
Tradename:	優替帝
Legal Status:	Rx in China
Synonyms:	Epothilone D; desoxyepothilone B
Cas Number:	189453-10-9
Pubchem:	447865
Drugbank:	DB17575
C:	27
H:	41
N:	1
O:	5
S:	1

Utidelone is a pharmaceutical drug for the treatment of metastatic breast cancer. It was approved for use in China in 2021.^{[1] [2]}

Utidelone is a member of the epothilone class of natural products, which are metabolites produced by the soil-dwelling myxobacterium Sorangium cellulosum.^[3] It is also known as epothilone D.

Notes and References

1. Web site: New Drug Approvals in China in 2021 . diaglobal.org. 2 May 2022 .
2. Villegas C, González-Chavarría I, Burgos V, Iturra-Beiza H, Ulrich H, Paz C . Epothilones as Natural Compounds for Novel Anticancer Drugs Development . International Journal of Molecular Sciences . 24 . 7 . 6063 . March 2023 . 37047035 . 10093981 . 10.3390/ijms24076063 . free .
3. Avendaño C, Menéndez JC . Anticancer drugs targeting tubulin and microtubules . Medicinal Chemistry of Anticancer Drugs . 2023 . 445–491 . 10.1016/B978-0-12-818549-0.00017-0. 978-0-12-818549-0 .