Ubiquitinyl hydrolase 1 explained

Ubiquitinyl hydrolase 1
Ec Number:	3.4.19.12
Cas Number:	86480-67-3, 189642-63-5

Ubiquitinyl hydrolase 1 (ubiquitin C-terminal hydrolase, yeast ubiquitin hydrolase) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin

This enzyme hydrolyses links to polypeptides smaller than 60 residues faster than those to larger polypeptides.

Notes and References

1. Johnston SC, Larsen CN, Cook WJ, Wilkinson KD, Hill CP . Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution . The EMBO Journal . 16 . 13 . 3787–96 . July 1997 . 9233788 . 1170002 . 10.1093/emboj/16.13.3787 .
2. Book: Ubiquitin C-terminal hydrolase . Handbook of Proteolytic Enzymes . Wilkinson, K.D. . 1998 . 470–472 . Barrett, A.J. . Rawlings, N.D. . Woessner, J.F. . Academic Press . London .