Tyrosine-ester sulfotransferase explained

tyrosine-ester sulfotransferase
Ec Number:	2.8.2.9
Cas Number:	9055-56-5
Go Code:	0017067

In enzymology, a tyrosine-ester sulfotransferase is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + L-tyrosine methyl ester

\rightleftharpoons adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and L-tyrosine methyl ester, whereas its two products are adenosine 3',5'-bisphosphate and L-tyrosine methyl ester 4-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase. Other names in common use include aryl sulfotransferase IV, and L-tyrosine methyl ester sulfotransferase.

References

• Duffel MW, Jakoby WB . 1981 . On the mechanism of aryl sulfotransferase . J. Biol. Chem. . 256 . 11123 - 7 . 6945304 . 21 .
• Mattock P, Jones JG . 1970 . Partial purification and properties of an enzyme from rat liver that catalyses the sulphation of L-tyrosyl derivatives . Biochem. J. . 116 . 797 - 803 . 5441369 . 5 . 1185501 .
• Sekura RD, Jakoby WB . 1981 . Aryl sulfotransferase IV from rat liver . Arch. Biochem. Biophys. . 211 . 352 - 9 . 6946725 . 10.1016/0003-9861(81)90464-1 . 1 .