| Cabinet Name: | Second Shamir Cabinet |
| Cabinet Number: | 22nd |
| Jurisdiction: | Israel |
| Flag: | Flag of Israel.svg |
| Flag Border: | true |
| Government Head: | Yitzhak Shamir |
| State Head: | Chaim Herzog |
| Legislature Status: | National Unity Rotation government |
| Political Parties: | Likud Alignment Shinui (until 26 May 1987) Shas National Religious Party Ometz Agudat Yisrael |
| Previous: | 21st Cabinet of Israel |
| Successor: | 23rd Cabinet of Israel |
| Legislature Term: | 11th Knesset |
| Opposition Leader: | Yuval Ne'eman |
The twenty-second government of Israel was formed by Yitzhak Shamir of Likud on 20 October 1986. Shamir replaced Shimon Peres of the Alignment as Prime Minister as part of a rotation deal within the national unity coalition between the two parties.[1] The only other change to the coalition was that the one-seat Morasha faction was not included, with the National Religious Party, Agudat Yisrael, Shas, Shinui and Ometz remaining part of the government, although Shinui left on 26 May 1987.
The government held office until 22 December 1988, when the twenty-third government was formed, following the November 1988 elections.