Tumor promotion explained
Tumor promotion is a process in carcinogenesis by which various factors permit the descendants of a single initiated cell to survive and expand in number, i.e. to resist apoptosis and to undergo clonal growth.[1] This is a step toward tumor progression.[2] [3]
In order for a tumor cell to survive, it must decrease its expression of tumor suppressor genes such as p53, BRCA1, BRCA2, RB1, or the fas receptor.[4] [5] A tumor suppressor would trigger an apoptotic pathway in a cancer cell if there were DNA damage, polyploidy, or uncontrolled cell growth.
Simultaneously, tumor cells need to upregulate oncogenes, which promote or cause downstream activation of growth factors and cell survival signals such as RAS,[6] Mitogen-activated protein kinase kinase, VEGF, or Akt.[7]
See also
Notes and References
- Book: Compton C . Cancer initiation, promotion, and progression and the acquisition of key behavioral traits. . Cancer: The Enemy from Within . 2020 . 25–48 . Springer . Cham . 10.1007/978-3-030-40651-6_2 . 978-3-030-40650-9 . 218945664 .
- Rakoff-Nahoum S . Why cancer and inflammation? . The Yale Journal of Biology and Medicine . 79 . 3–4 . 123–130 . December 2006 . 17940622 . 1994795 .
- Web site: NCI Dictionary of Cancer Terms:Tumor promotion . National Cancer Institute . 10 Nov 2012.
- Book: https://www.ncbi.nlm.nih.gov/books/NBK9894/ . Tumor Suppressor Genes . The Cell: A Molecular Approach. . 2nd . 2000 . Cooper GM . Sinauer Associates .
- Web site: Oncogenes, Tumor Suppressor Genes, and Cancer . American Cancer Society .
- https://www.cancerquest.org/cancer-biology/cancer-genes#ras Cancer Genes: RAS
- Web site: Oncogenes, Tumor Suppressor Genes, and Cancer . American Cancer Society .
