Tubulinyl-Tyr carboxypeptidase explained

Tubulinyl-Tyr carboxypeptidase
Ec Number:	3.4.17.17
Cas Number:	73050-23-4

Tubulinyl-Tyr carboxypeptidase (carboxypeptidase-tubulin, soluble carboxypeptidase, tubulin-tyrosine carboxypeptidase, tubulin carboxypeptidase, tubulinyltyrosine carboxypeptidase, tyrosinotubulin carboxypeptidase, tyrosyltubulin carboxypeptidase, TTCPase, brain I carboxypeptidase) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleavage of the -Glu--Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr

This enzyme is active at neutral pH.

This activity has been linked to proteins such as AGTPBP1 in human.^[4]

Notes and References

1. Argarana CE, Barra HS, Caputto R . Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification . Journal of Neurochemistry . 34 . 1 . 114–8 . January 1980 . 7452228 . 10.1111/j.1471-4159.1980.tb04628.x .
2. Kumar N, Flavin M . Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin . The Journal of Biological Chemistry . 256 . 14 . 7678–86 . July 1981 . 10.1016/S0021-9258(19)69014-9 . free . 6114100 .
3. Arce CA, Barra HS . Association of tubulinyl-tyrosine carboxypeptidase with microtubules . FEBS Letters . 157 . 1 . 75–8 . June 1983 . 6862022 . 10.1016/0014-5793(83)81119-3 . free .
4. Rodriguez de la Vega M, Sevilla RG, Hermoso A, Lorenzo J, Tanco S, Diez A, Fricker LD, Bautista JM, Avilés FX . Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily . FASEB Journal . 21 . 3 . 851–65 . March 2007 . 17244817 . 10.1096/fj.06-7330com . free .