| Tubulin—tyrosine ligase | |
| Ec Number: | 6.3.2.25 |
| Cas Number: | 60321-03-1 |
| Go Code: | 0004835 |
In enzymology, a tubulin—tyrosine ligase is an enzyme that catalyzes the chemical reaction
ATP + detyrosinated α-tubulin + L-tyrosine
\rightleftharpoons
The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).