Tryptophan alpha,beta-oxidase explained

tryptophan alpha,beta-oxidase
Ec Number:	1.3.3.10
Cas Number:	156859-19-7
Go Code:	0050621

In enzymology, a tryptophan alpha,beta-oxidase is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂

\rightleftharpoons alpha,beta-didehydrotryptophan + H₂O₂

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its two products are alpha,beta-didehydrotryptophan and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-tryptophan:oxygen alpha,beta-oxidoreductase. Other names in common use include L-tryptophan 2',3'-oxidase, and L-tryptophan alpha,beta-dehydrogenase. It employs one cofactor, heme.

References

• Genet R, Denoyelle C, Menez A . 1994 . Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum . J. Biol. Chem. . 269 . 18177 - 84 . 8027079 . 27 .
• Genet R, Benetti PH, Hammadi A, Menez A . 1995 . L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications . J. Biol. Chem. . 270 . 23540 - 5 . 7559518 . 40 . 10.1074/jbc.270.40.23540. free .