| tryptophan-tRNA ligase | |
| Ec Number: | 6.1.1.2 |
| Cas Number: | 9023-44-3 |
| Go Code: | 0004830 |
In enzymology, a tryptophan-tRNA ligase is an enzyme that catalyzes the chemical reaction
ATP + L-tryptophan + tRNATrp
\rightleftharpoons
The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp.
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.
As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,,, and .