Tropomyosin kinase explained

tropomyosin kinase
Ec Number:	2.7.11.28
Cas Number:	90804-56-1
Go Code:	0050359

In enzymology, a tropomyosin kinase is an enzyme that catalyzes the chemical reaction

ATP + tropomyosin

\rightleftharpoons ADP + O-phosphotropomyosin

Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.

References

• deBelle I, Mak AS . 1987 . Isolation and characterization of tropomyosin kinase from chicken embryo . Biochim. Biophys. Acta . 925 . 17 - 26 . 3593768 . 1 . 10.1016/0304-4165(87)90143-7.
• Montgomery K, Mak AS . 1984 . In vitro phosphorylation of tropomyosin by a kinase from chicken embryo . J. Biol. Chem. . 259 . 5555 - 60 . 6325440 . 9 .
• Watson MH, Taneja AK, Hodges RS, Mak AS . 1988 . Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues . Biochemistry . 27 . 4506 - 12 . 3166994 . 10.1021/bi00412a043 . 12 .