Tropinone reductase I explained
| tropine dehydrogenase |
| Ec Number: | 1.1.1.206 |
| Cas Number: | 118390-87-7 |
| Go Code: | 0050356 |
In enzymology, a tropinone reductase I is an enzyme that catalyzes the chemical reaction
tropine + NADP+
tropinone + NADPH + H
+Thus, the two substrates of this enzyme are tropine and NADP+, whereas its 3 products are tropinone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is tropine:NADP+ 3alpha-oxidoreductase. Other names in common use include tropine dehydrogenase, tropinone reductase (ambiguous), and TR-I. This enzyme participates in alkaloid biosynthesis ii.
References
- Koelen KJ . Gross, GG . 1982 . Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium . Planta Med. . 44 . 227 - 230 . 10.1055/s-2007-971454 . 17402126 . 4 .
- Couladis MM, Friesen JB, Landgrebe ME, Leete E . 1991 . Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia . Phytochemistry . 30 . 801 - 805 . 10.1016/0031-9422(91)85255-X . 3 .
- Nakajima K, Hashimoto T, Yamada Y . 1993 . Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor . Proc. Natl. Acad. Sci. U.S.A. . 90 . 9591 - 5 . 8415746 . 10.1073/pnas.90.20.9591 . 20 . 47615 . 1993PNAS...90.9591N . free .
- Drager B . 2006 . Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism . . 67 . 327 - 37 . 16426652 . 10.1016/j.phytochem.2005.12.001 . 4 .
