Tropine acyltransferase explained

Tropine acyltransferase
Ec Number:	2.3.1.185
Cas Number:	138440-79-6, 162535-29-7

Tropine acyltransferase (tropine:acyl-CoA transferase, acetyl-CoA:tropan-3-ol acyltransferase, tropine acetyltransferase, tropine tigloyltransferase, TAT) is an enzyme with systematic name acyl-CoA:tropine O-acyltransferase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

\rightleftharpoons CoA + O-acyltropine

This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as pseudotropine.

Notes and References

1. Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y . The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases . FEBS Letters . 292 . 1-2 . 293–7 . November 1991 . 1959620 . 10.1016/0014-5793(91)80887-9 . free .
2. Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures . Robins, R.J. . Bachmann,P. . Peerless, A.C.J. . Rabot, S. . Plant Cell Tissue Organ Cult. . 1994 . 38 . 241–247 . 10.1007/bf00033883.
3. Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ . Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura . Phytochemistry . 52 . 5 . 871–8 . November 1999 . 10626376 . 10.1016/S0031-9422(99)00293-9 .
4. Li R, Reed DW, Liu E, Nowak J, Pelcher LE, Page JE, Covello PS . Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement . Chemistry & Biology . 13 . 5 . 513–20 . May 2006 . 16720272 . 10.1016/j.chembiol.2006.03.005 . free .