Tropine Explained

Tropine is a derivative of tropane containing a hydroxyl group at the third carbon. It is also called 3-tropanol. It is a poisonous white hygroscopic crystalline powder. It is a heterocyclic alcohol and an amine.

Tropine is a central building block of many chemicals active in the nervous system, including tropane alkaloids. Some of these compounds, such as long-acting muscarinic antagonists are used as medicines because of these effects.[1]

Occurrence

Tropine is a natural product found in the plants of deadly nightshade (Atropa belladonna) and devil's trumpet (Datura stramonium).

Chemistry

Synthesis

It can be prepared by hydrolysis of atropine[2] or other solanaceous alkaloids.

See also

Notes and References

  1. Ping . Yu . Li . Xiaodong . You . Wenjing . Li . Guoqiang . Yang . Mengquan . Wei . Wenping . Zhou . Zhihua . Xiao . Youli . Production of the Plant-Derived Tropine and Pseudotropine in Yeast . ACS Synthetic Biology . 10 June 2019 . 8 . 6 . 1257–1262 . 10.1021/acssynbio.9b00152. 31181154 . 184484993 .
  2. Web site: https://www.seanmichaelragan.com/html/[2008-09-10_Cocaine_analog_in_two_steps_from_native_plant_material.shtml Cocaine analog in two steps from native plant material].