Triphenylmethylethylene Explained

Triphenylmethylethylene, also known as methyltriphenylethylene or as triphenylpropene, is a synthetic nonsteroidal estrogen of the triphenylethylene group that is related to triphenylchloroethylene and was never marketed.^{[1] [2]} Along with diethylstilbestrol and triphenylchoroethylene, triphenylmethylethylene was studied in 1944 by Sir Alexander Haddow for the treatment of breast cancer, and this is historically notable in that it was the first time that high-dose estrogens were found to be effective in the treatment of breast cancer.^[3] However, while diethylstilbestrol and triphenylchloroethylene were found to be significantly effective, triphenylmethylethylene was less effective and showed a favorable response in only 1 of 4 treated cases.^{[4] [5]}

See also

• Triphenylbromoethylene
• Triphenyliodoethylene

Notes and References

1. Book: V. Craig Jordan. Estrogen Action, Selective Estrogen Receptor Modulators, and Women's Health: Progress and Promise. 2013. World Scientific. 978-1-84816-958-6. 42–43.
2. Book: Hormones and Breast Cancer. 25 June 2013. Elsevier. 978-0-12-416676-9. 9–.
3. Book: D. J. Th. Wagener. The History of Oncology. 13 July 2009. Bohn Stafleu van Loghum. 978-90-313-6143-4. 189–.
4. Obiorah I, Jordan VC . Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality . Menopause . 20 . 4 . 372–82 . 2013 . 23921472 . 3740456 . 10.1097/GME.0b013e31828865a5 . Of 4 cases of breast cancer treated with triphenylmethylethylene, only one showed a favorable response..
5. Book: Sir James Hopwood Jeans. The physics of the universe. 1928. Printed by R. & R. Clark, limited. 486. Triphenylmethylethylene was less effective than either stilbcestrol or triphenylchloroethylene..