Triphenylethanol Explained

Triphenylethanol, or 1,1,2-triphenylethanol, is an organic compound with a condensed structural formula of, and is related to triphenylethylene, from which it can be prepared by hydration. It is the structural analog of two drugs, the never-marketed antiestrogen ethamoxytriphetol (MER-25)^[1] and the withdrawn lipid-lowering agent triparanol,^[2] as both contain the 1,1,2-triphenylethanol moiety within their structure.

There are three isomeric compounds with a "triphenylethanol" structure:

• 1,1,2-triphenylethanol;
• 1,2,2-triphenylethanol, with a condensed structural formula of, which exists as a pair of enantiomers; and,
• 2,2,2-triphenylethanol, with a condensed structural formula of .

Notes and References

1. Book: Jordan, V. Craig. V. Craig Jordan

   . V. Craig Jordan. V. Craig Jordan. Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health: Progress and Promise. https://books.google.com/books?id=ZM26CgAAQBAJ&pg=PA7. 2013. World Scientific. 978-1-84816-959-3. A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention. 1–29. V. Craig. Jordan.

2. Book: Bulletin of the National Institute of Sciences of India. 1964. National Institute of Sciences of India. 5.