Trimetrexate Explained

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.[1]

Uses

It has been used with leucovorin in treating pneumocystis pneumonia.[2]

It has been investigated for use in treating leiomyosarcoma.[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. [4]

Notes and References

  1. Wong BK, Woolf TF, Chang T, Whitfield LR . Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog . Drug Metab. Dispos. . 18 . 6 . 980–6 . 1990 . 1981548 .
  2. Sattler FR, Allegra CJ, Verdegem TD, etal . Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia . J. Infect. Dis. . 161 . 1 . 91–6 . January 1990 . 2136905 . 10.1093/infdis/161.1.91.
  3. Smith HO, Blessing JA, Vaccarello L . Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group . Gynecol. Oncol. . 84 . 1 . 140–4 . January 2002 . 11748990 . 10.1006/gyno.2001.6482 .
  4. Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.

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