Trimethylamine-corrinoid protein Co-methyltransferase explained

Trimethylamine-corrinoid protein Co-methyltransferase
Ec Number:	2.1.1.250

Trimethylamine-corrinoid protein Co-methyltransferase (mttB (gene), trimethylamine methyltransferase) is an enzyme with systematic name trimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

trimethylamine + [Co(I) trimethylamine-specific corrinoid protein]

\rightleftharpoons [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine

This enzyme is involved in methanogenesis from trimethylamine.

Notes and References

1. Ferguson DJ, Krzycki JA . Reconstitution of trimethylamine-dependent coenzyme M methylation with the trimethylamine corrinoid protein and the isozymes of methyltransferase II from Methanosarcina barkeri . Journal of Bacteriology . 179 . 3 . 846–52 . February 1997 . 9006042 . 178769 . 10.1128/jb.179.3.846-852.1997 .
2. Krzycki JA . Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases . Current Opinion in Chemical Biology . 8 . 5 . 484–91 . October 2004 . 15450490 . 10.1016/j.cbpa.2004.08.012 .