Trimethylamine dehydrogenase explained
| trimethylamine dehydrogenase |
| Ec Number: | 1.5.8.2 |
| Cas Number: | 39307-09-0 |
| Go Code: | 0050470 |
In enzymology, a trimethylamine dehydrogenase is an enzyme that catalyzes the chemical reaction
trimethylamine + H2O + electron-transferring flavoprotein
dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
The 3 substrates of this enzyme are trimethylamine, H2O, and electron-transferring flavoprotein, whereas its 3 products are dimethylamine, formaldehyde, and reduced electron-transferring flavoprotein.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating). This enzyme participates in methane metabolism.
References
- Colby J . Zatman LJ . 1971 . The purification and properties of a bacterial trimethylamine dehydrogenase . Biochem. J. . 121 . 1 . 9P–10P . 5116569 . 1176516.
- Steenkamp DJ, Singer TP . 1978 . Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis . Biochem. J. . 169 . 361 - 9 . 204297 . 2 . 1184175 .
- Huang L, Rohlfs RJ, Hille R . 1995 . The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein . J. Biol. Chem. . 270 . 23958 - 65 . 7592591 . 10.1074/jbc.270.41.23958 . 41 . free .
- Jones M . 2002 . Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein . J. Biol. Chem. . 277 . 8457 - 65 . 11756429 . 10.1074/jbc.M111105200 . Talfournier . F . Bobrov . A . Grossmann . JG . Vekshin . N . Sutcliffe . MJ . Scrutton . NS . 10 . free .
- Scrutton NS, Sutcliffe MJ . 2000 . Trimethylamine dehydrogenase and electron transferring flavoprotein . Subcell. Biochem. . 35 . 145 - 81 . 11192721 . 10.1007/0-306-46828-X_5 .
