Trimethoprim/sulfadoxine explained

Type:	combo
Component1:	Trimethoprim
Class1:	Dihydrofolate reductase inhibitor
Component2:	Sulfadoxine
Class2:	Sulfonamide antibiotic
Tradename:	Trimidox
Cas Number:	95933-74-7

Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both gram-negative and gram-positive bacteria.^[1]

Veterinary uses

Trimethoprim/sulfadoxine is used in the treatment of swine and cattle, including dairy cattle, beef cattle and veal.

In cattle, it is used to treat:

• Respiratory tract infections such as bovine pneumonia pasteurellosis (shipping fever)^[1]
• Alimentary tract infections such as salmonellosis and both enteric and septicaemic colibacillosis^[1]
• Other infections such as pododermatitis (foot rot) and septicaemias^[1]

In swine, it is used to treat:

• Respiratory tract infections such as bacterial pneumonias^[1]
• Alimentary tract infections such as post-weaning scours and colibacillosis^[1]
• Other infections such as bacterial arthritis and mastitis-metritis-agalactia syndrome in sows.^[1]

Contraindications

Trimethoprim/sulfadoxine is contraindicated in cattle or swine that show marked liver parenchymal damage or blood dyscrasias, or those with a history of sulfonamide sensitivity.^[1]

Milk from an animal treated with trimethoprim/sulfadoxine must not be consumed for at least 96 hours following the most recent treatment; treated animals must not be slaughtered for use in food for at least ten days after the last treatment.^[1]

Notes and References

1. Web site: Trimidox. Vetoquinol Canada Inc.. 11 November 2011.