Trimerelysin I Explained

Trimerelysin I
Ec Number:3.4.24.52
Cas Number:151125-16-5

Trimerelysin I (Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Cleavage of only two bonds His10-Leu and Ala14-Leu in the insulin B chain

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

Notes and References

  1. Omori-Satoh T, Sadahiro S . Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts . Biochimica et Biophysica Acta (BBA) - Protein Structure . 580 . 2 . 392–404 . October 1979 . 518906 . 10.1016/0005-2795(79)90151-x .
  2. Yamakawa Y, Omori-Satoh T . The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis) . Toxicon . 26 . 2 . 227–31 . 1988 . 3284004 . 10.1016/0041-0101(88)90178-x .
  3. Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S . The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis . The Journal of Biological Chemistry . 265 . 27 . 16068–73 . September 1990 . 2398046 .

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