Trimebutine Explained

Trimebutine is a drug with antimuscarinic and very weak mu opioid agonist effects.^[1] It is used for the treatment of irritable bowel syndrome and other gastrointestinal disorders.

The major product from drug metabolism of trimebutine in human beings is nortrimebutine,^[2] which comes from removal of one of the methyl groups attached to the nitrogen atom. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract.^[3]
Both trimebutine and its metabolite are commercially available.

Brand names

The maleic acid salt of trimebutine is marketed under the trademarks of Antinime, Cineprac, Colospasmyl, Colypan, Crolipsa, Debricol, Debridat, Digedrat, Espabion, Gast Reg, Irritratil, Krisxon, Muttifen, Neotina, Polybutin,^[4] Sangalina, Trebutel, Tribudat, Tributina, Trim, Trimeb, Trimedat, and Trimedine.

See also

• Asimadoline
• Fedotozine

Notes and References

1. Kaneto H, Takahashi M, Watanabe J . The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies . Journal of Pharmacobio-Dynamics . 13 . 7 . 448–53 . July 1990 . 1963196 . 10.1248/bpb1978.13.448 . free . 10069/38849 . free .
2. Roman FJ, Lanet S, Hamon J, Brunelle G, Maurin A, Champeroux P, Richard S, Alessandri N, Gola M . 6 . Pharmacological properties of trimebutine and N-monodesmethyltrimebutine . The Journal of Pharmacology and Experimental Therapeutics . 289 . 3 . 1391–7 . June 1999 . 10336531 .
3. Hiyama T, Yoshihara M, Tanaka S, Haruma K, Chayama K . Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract . Journal of Gastroenterology and Hepatology . 24 . 4 . 537–46 . April 2009 . 19220673 . 10.1111/j.1440-1746.2009.05780.x . 25767036 . free .
4. Jhee OH, Lee YS, Shaw LM, Jeon YC, Lee MH, Lee SH, Kang JS . Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC-MS/MS method . Clinica Chimica Acta; International Journal of Clinical Chemistry . 375 . 1–2 . 69–75 . January 2007 . 16854404 . 10.1016/j.cca.2006.06.006 .