Triacylglycerol lipase explained

Triacylglycerol lipase
Ec Number:	3.1.1.3
Cas Number:	9001-62-1

The enzyme triacylglycerol lipase (also triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) catalyses the hydrolysis of ester linkages of triglycerides:^[1]

triacylglycerol + H₂O diacylglycerol + a carboxylate

These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.^{[2] [3] [4] [5] [6]}

Human proteins containing this domain

DAGLA

DAGLB; LOC221955;The pancreatic enzyme acts only on an ester-water interface.

Nomenclature

Other names include lipase, butyrinase, tributyrinase, Tween hydrolase, steapsin, triacetinase, tributyrin esterase, Tweenase, amno N-AP, Takedo 1969-4-9, Meito MY 30, Tweenesterase, GA 56, capalase L, triglyceride hydrolase, triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, amano AP, PPL, glycerol-ester hydrolase, GEH, meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin lipase, heparin releasable hepatic lipase, amano CES, amano B, tributyrase, triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase).

See also

• Pancreatic lipase
• Gastric lipase
• Lingual lipase

Notes and References

1. Chapus C, Rovery M, Sarda L, Verger R . Minireview on pancreatic lipase and colipase . Biochimie . 70 . 9 . 1223–1234 . 1988 . 3147715 . 10.1016/0300-9084(88)90188-5.
2. Korn ED, Quigley TW . Lipoprotein lipase of chicken adipose tissue . The Journal of Biological Chemistry . 226 . 2 . 833–9 . June 1957 . 10.1016/S0021-9258(18)70867-3 . 13438870 . free .
3. Lynn WS, Perryman NC . Properties and purification of adipose tissue lipase . The Journal of Biological Chemistry . 235 . 1912–6 . July 1960 . 7 . 10.1016/S0021-9258(18)69335-4 . 14419169 . free .
4. Sarda L, Desnuelle P . [Actions of pancreatic lipase on esters in emulsions] . Biochimica et Biophysica Acta . 30 . 3 . 513–21 . December 1958 . 13618257 . 10.1016/0006-3002(58)90097-0 .
5. Studies on wheat germ lipase. I. Methods of estimation, purification and general properties of the enzyme . Singer, T.P. . Hofstee, B.H.J. . Arch. Biochem. . 1948 . 18 . 2 . 229–243 . 18875045.
6. Studies on wheat germ lipase. II. Kinetics . Singer, T.P. . Hofstee, B.H.J. . Arch. Biochem. . 1948 . 18 . 2 . 245–259 . 18875046.