Tribenoside Explained

Tribenoside (Glyvenol) is a vasoprotective drug used to treat hemorrhoids.^[1] It has mild anti-inflammatory, analgesic, and wound healing properties.^[2] Tribenoside stimulates laminin α5 production and laminin-332 deposition to help repair the basement membrane during the wound healing process.^[3] It is a mixture of the α- and β-anomers.

Tribenoside has been shown to induce drug hypersensitivity syndrome in association with CMV reactivation.^[4]

Notes and References

1. Lorenc Z, Gökçe Ö . Tribenoside and lidocaine in the local treatment of hemorrhoids: an overview of clinical evidence. . Eur Rev Med Pharmacol Sci . 2016 . 20 . 12 . 2742–51 . 27383331 .
2. Jaques R . The pharmacological activity of tribenoside. . Pharmacology . 1977 . 15 . 5 . 445–60 . 578928 . 10.1159/000136721 .
3. Kikkawa Y, Takaki S, Matsuda Y, Okabe K, Taniguchi M, Oomachi K, Samejima T, Katagiri F, Hozumi K, Nomizu M . The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cells. . Biol Pharm Bull . 2010 . 33 . 2 . 307–10 . 20118558 . 10.1248/bpb.33.307 . free .
4. Hashizume H, Takigawa M . Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation: immunological characterization of pathogenic T cells . Acta Derm. Venereol. . 85 . 1 . 47–50 . 2005 . 15848991 . 10.1080/00015550410024094 . free .