Tribendimidine Explained

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis.[2] It is also effective against clonorchiasis.[3] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.[4]

Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.

Notes and References

  1. Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J . Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini . Antimicrobial Agents and Chemotherapy . 51 . 3 . 1096–1098 . March 2007 . 17194822 . 1803157 . 10.1128/AAC.01366-06 . Free full text.
  2. Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W . Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China . Acta Tropica . 94 . 1 . 1–14 . April 2005 . 15777691 . 10.1016/j.actatropica.2005.01.013 .
  3. Zhang H, Liu C, Zheng Q . Development and application of anthelminthic drugs in China . Acta Tropica . 200 . 105181 . December 2019 . 31542370 . 10.1016/j.actatropica.2019.105181 . free .
  4. News: Kelland K . New drug shows promise against Asian liver fluke. 2010-11-24 . Reuters .

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