Trapidil Explained

Trapidil is a vasodilator and an antiplatelet drug.^{[1] [2]} It also acts as an antagonist of platelet-derived growth factor.^[3]

An analog was assigned the codename AR 12-456.^[4]

Notes and References

1. Büyükafşar K, Yazar A, Düşmez D, Oztürk H, Polat G, Levent A . Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats . Pharmacological Research . 44 . 4 . 321–328 . October 2001 . 11592868 . 10.1006/phrs.2001.0864 .
2. Liu M, Sun Q, Wang Q, Wang X, Lin P, Yang M, Yan Y . Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit . Indian Journal of Pharmacology . 46 . 2 . 207–210 . March–April 2014 . 24741195 . 3987192 . 10.4103/0253-7613.129320 . free .
3. Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, Fontanelli A, Monici Preti PA, Repetto S, De Servi S . 6 . Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica . Circulation . 90 . 6 . 2710–2715 . December 1994 . 7994812 . 10.1161/01.cir.90.6.2710 . free .
4. Hering S, Bodewei R, Schubert B, Krause EG, Wollenberger A . Trapidil and other 5-triazolo-(1, 5-alpha)-pyrimidine derivatives as calcium channel blockers in 108CC5 cells . Biomedica Biochimica Acta . 44 . 5 . K37–K41 . 1985 . 2415119 .