Clonally transmissible cancer explained

A transmissible cancer is a cancer cell or cluster of cancer cells that can be transferred between individuals without the involvement of an infectious agent, such as an oncovirus.[1] The evolution of transmissible cancer has occurred naturally in other animal species, but human cancer transmission is rare.[2] This transfer is typically between members of the same species or closely related species.[3]

General mechanism

Transmissible cancers require a specific combination of related circumstances to occur. These conditions involve both the host species and the tumors being transferred. These typically include low genetic diversity among individuals, an effective physical and environmental transport system, and a high enough dose of infective material.[4] The cancers reproduce faster in larger quantities with different means of reproduction tend to be favored for transmission if host conditions are met. Transmissible cancers follow the general pattern of cancer spread, starting with the growth of primary cancer cells at tumor sites followed by invasion of surrounding tissue and subsequent spread throughout the organism.[5] The main hurdles for surviving cells of a successful spread to a new host are histocompatibility barriers. The cancers have to bypass the self recognition system, survive the difference in nutrients and induce the correct response in the new hosts to begin the cycle anew.[6]

Transmissible cancers behave as true parasites, relying primarily on transport systems like direct contact, environmental transport and vectors, rather than hematogenous and lymphatic carriers to spread between organisms. The amount of shredded cancer cells from initial host has to be high enough to increase survival probability. Direct contact transmissions through sexual or general contact such as in DFTD and CVTD ensures a higher potential for transmission. Population factors also play an important role. A dense population of available and uninfected potential hosts is ideal for the tumors given the complexity and difficulty of the overall process, hence its virulence and potency must be adequately controlled.

Humans

In humans, a significant fraction of Kaposi's sarcoma occurring after transplantation may be due to tumorous outgrowth of donor cells.[7] Although Kaposi's sarcoma is caused by a virus (Kaposi's sarcoma-associated herpesvirus), in these cases, it appears likely that transmission of virus-infected tumor cells—rather than the free virus—caused tumors in the transplant recipients.[2]

In 2007, four people (three women and one man) received different organ transplants (liver, both lungs and kidneys) from a 53-year-old woman who had recently died from intracranial bleeding. Before transplantation, the organ donor was deemed to have no signs of cancer upon medical examination. The organ recipients developed metastatic breast cancer from the organs and three of them died from the cancer between 2009–2017.[8]

In 2014, a case of parasite-to-host cancer transmission occurred in a 41-year-old man in Colombia with a compromised immune system due to HIV. The man's tumor cells were shown to have originated from the dwarf tapeworm, Hymenolepis nana.[9] In the 1990s, an undifferentiated pleomorphic sarcoma was transmitted from a 32-year-old patient to his 53-year-old surgeon when the surgeon injured his hand during an operation. Within five months, a tumor had developed on the hand of the surgeon and was subsequently excised. Histologic examinations of the tumor tissues from the patient and surgeon showed that both were morphologically identical.[10] In 1986, a 19-year-old laboratory worker mistakenly punctured her hand with a needle previously used to extract human colonic cancer cells. No injection of the substance occurred, and the worker suffered a small puncture wound with bleeding. Within 19 days, she had developed a small cancerous nodule on her hand. The tumor was removed soon after, and has since shown no sign of reoccurrence.[11]

Other animals

Contagious cancers are known to occur in dogs, Tasmanian devils, Syrian hamsters, and some marine bivalves including soft-shell clams. These cancers have a relatively stable genome as they are transmitted.[12] Recent studies have tested whether other highly prevalent wildlife cancers, such as urogenital carcinomas in Californian sea lions, could also be contagious but so far there is no evidence for this.[13]

Clonally transmissible cancer, caused by a clone of malignant cells rather than a virus,[14] is an extremely rare disease modality,[15] with few transmissible cancers being known.[1] The evolution of transmissible cancer is unlikely, because the cell clone must be adapted to survive a physical transmission of living cells between hosts, and must be able to survive in the environment of a new host's immune system.[16] Animals that have undergone population bottlenecks may be at greater risks of contracting transmissible cancers due to a lack of overall genetic diversity. Infectious cancers may also evolve to circumvent immune response by means of natural selection in order to spread.[17] Because of their transmission, it was initially thought that these diseases were caused by the transfer of oncoviruses, in the manner of cervical cancer caused by human papillomavirus.[2] However, canine transmissible venereal tumor mutes the expression of the immune response, whereas the Syrian hamster disease spreads due to lack of genetic diversity.[18]

Canine transmissible venereal tumor

See main article: article and Canine transmissible venereal tumor. Canine transmissible venereal tumor (CTVT) is sexually transmitted cancer which induces cancerous tumors on the genitalia of both male and female dogs, typically during mating. It was first described medically by a veterinary practitioner in London in 1810.[19] It was experimentally transplanted between dogs in 1876 by M. A. Novinsky (1841–1914). A single malignant clone of CTVT cells has colonized dogs worldwide, representing the oldest known malignant cell line in continuous propagation,[20] a fact that was uncovered in 2006. Researchers deduced that the CTVT went through 2 million mutations to reach its actual state, and inferred it started to develop in ancient dog species 11 000 years ago.[19]

Contagious reticulum cell sarcoma

See main article: article and Contagious reticulum cell sarcoma. Contagious reticulum cell sarcoma of the Syrian hamster[21] can be transmitted from one Syrian hamster to another through various mechanisms. It has been seen to spread within a laboratory population, presumably through gnawing at tumours and cannibalism.[1] It can also be spread by means of the bite of the mosquito Aedes aegypti.[22]

Devil facial tumour disease

See main article: article and Devil facial tumour disease. Devil facial tumour disease (DFTD) is a transmissible parasitic cancer in the Tasmanian devil.[23] Since its discovery in 1996, DFTD has spread and infected 4/5 of all Tasmanian devils and threatens them with extinction. DFTD has a near 100% fatality rate, and has killed up to 90% of Tasmanian devil populations living in some reserves.[24] A new DFTD tumor-type cancer was recently uncovered on 5 Tasmanian devils (DFT2), histologically different from DFT1, leading researchers to believe that the Tasmanian devil "is particularly prone to the emergence of transmissible cancers".[19]

Bivalves

Soft-shell clams, Mya arenaria, have been found to be vulnerable to a transmissible neoplasm of the hemolymphatic system — effectively, leukemia.[25] [26] The cells have infected clam beds hundreds of miles from each other, making this clonally transmissible cancer the only one that does not require contact for transmission.[19]

Horizontally transmitted cancers have also been discovered in three other species of marine bivalves: bay mussels (Mytilus trossulus), common cockles (Cerastoderma edule) and golden carpet shell clams (Polititapes aureus). The golden carpet shell clam cancer was found to have been transmitted from another species, the pullet carpet shell (Venerupis corrugata).[27] [28]

See also

External links

Notes and References

  1. Ostrander EA, Davis BW, Ostrander GK . Transmissible Tumors: Breaking the Cancer Paradigm . Trends in Genetics . 32 . 1 . 1–15 . January 2016 . 26686413 . 4698198 . 10.1016/j.tig.2015.10.001 .
  2. Welsh JS . Contagious cancer . The Oncologist . 16 . 1 . 1–4 . 2011 . 21212437 . 3228048 . 10.1634/theoncologist.2010-0301 .
  3. Dujon . Antoine M. . Gatenby . Robert A. . Bramwell . Georgina . MacDonald . Nick . Dohrmann . Erin . Raven . Nynke . Schultz . Aaron . Hamede . Rodrigo . Gérard . Anne-Lise . Giraudeau . Mathieu . Thomas . Frédéric . Ujvari . Beata . July 2020 . Transmissible Cancers in an Evolutionary Perspective . iScience . en . 23 . 7 . 101269 . 10.1016/j.isci.2020.101269 . 7327844 . 32592998. 2020iSci...23j1269D .
  4. Ujvari . Beata . Gatenby . Robert A. . Thomas . Frédéric . 2016-04-01 . The evolutionary ecology of transmissible cancers . Infection, Genetics and Evolution . 39 . 293–303 . 10.1016/j.meegid.2016.02.005 . 26861618 . 2016InfGE..39..293U . 1567-1348.
  5. Nguyen . Don X. . Bos . Paula D. . Massagué . Joan . April 2009 . Metastasis: from dissemination to organ-specific colonization . Nature Reviews Cancer . 9 . 4 . 274–284 . 10.1038/nrc2622 . 19308067 . 1474-175X.
  6. Gatenby . Robert A. . Gillies . Robert J. . January 2008 . A microenvironmental model of carcinogenesis . Nature Reviews Cancer . 8 . 1 . 56–61 . 10.1038/nrc2255 . 18059462 . 1474-175X.
  7. Barozzi P, Luppi M, Facchetti F, Mecucci C, Alù M, Sarid R, Rasini V, Ravazzini L, Rossi E, Festa S, Crescenzi B, Wolf DG, Schulz TF, Torelli G . Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors . Nature Medicine . 9 . 5 . 554–61 . May 2003 . 12692543 . 10.1038/nm862 . 2527251 .
  8. Matser YA, Terpstra ML, Nadalin S, Nossent GD, de Boer J, van Bemmel BC, van Eeden S, Budde K, Brakemeier S, Bemelman FJ . Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients . American Journal of Transplantation . 18 . 7 . 1810–1814 . July 2018 . 29633548 . 10.1111/ajt.14766 . free .
  9. Muehlenbachs A, Bhatnagar J, Agudelo CA, Hidron A, Eberhard ML, Mathison BA, Frace MA, Ito A, Metcalfe MG, Rollin DC, Visvesvara GS, Pham CD, Jones TL, Greer PW, Vélez Hoyos A, Olson PD, Diazgranados LR, Zaki SR . Malignant Transformation of Hymenolepis nana in a Human Host . The New England Journal of Medicine . 373 . 19 . 1845–52 . November 2015 . 26535513 . 10.1056/NEJMoa1505892 . free .
  10. Gärtner HV, Seidl C, Luckenbach C, Schumm G, Seifried E, Ritter H, Bültmann B . Genetic analysis of a sarcoma accidentally transplanted from a patient to a surgeon . The New England Journal of Medicine . 335 . 20 . 1494–6 . November 1996 . 8890100 . 10.1056/NEJM199611143352004 . free .
  11. Gugel EA, Sanders ME . Needle-stick transmission of human colonic adenocarcinoma . The New England Journal of Medicine . 315 . 23 . 1487 . December 1986 . 3785302 . 10.1056/NEJM198612043152314 .
  12. Weiss RA, Fassati A, Murgia C . 2006. A sexually transmitted parasitic cancer. Retrovirology. 3. Supplement 1. S92. 1717007 . 10.1186/1742-4690-3-S1-S92. free.
  13. Ní Leathlobhair M, Gulland FM, Murchison EP . No evidence for clonal transmission of urogenital carcinoma in California sea lions (Zalophus californianus) . Wellcome Open Research . 2 . 46 . 2017-06-22 . 28948233 . 5527528 . 10.12688/wellcomeopenres.11483.1 . free .
  14. Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A . Origins and evolution of a transmissible cancer . Evolution; International Journal of Organic Evolution . 63 . 9 . 2340–9 . September 2009 . 19453727 . 10.1111/j.1558-5646.2009.00724.x . free .
  15. Strakova A, Murchison EP . The cancer which survived: insights from the genome of an 11000 year-old cancer . Current Opinion in Genetics & Development . 30 . 49–55 . February 2015 . 25867244 . 10.1016/j.gde.2015.03.005 . 21195930 .
  16. Baez-Ortega A, Gori K, Strakova A, Allen JL, Allum KM, Bansse-Issa L, Bhutia TN, Bisson JL, Briceño C, Castillo Domracheva A, Corrigan AM, Cran HR, Crawford JT, Davis E, de Castro KF, B de Nardi A, de Vos AP, Delgadillo Keenan L, Donelan EM, Espinoza Huerta AR, Faramade IA, Fazil M, Fotopoulou E, Fruean SN, Gallardo-Arrieta F, Glebova O, Gouletsou PG, Häfelin Manrique RF, Henriques JJ, Horta RS, Ignatenko N, Kane Y, King C, Koenig D, Krupa A, Kruzeniski SJ, Kwon YM, Lanza-Perea M, Lazyan M, Lopez Quintana AM, Losfelt T, Marino G, Martínez Castañeda S, Martínez-López MF, Meyer M, Migneco EJ, Nakanwagi B, Neal KB, Neunzig W, Ní Leathlobhair M, Nixon SJ, Ortega-Pacheco A, Pedraza-Ordoñez F, Peleteiro MC, Polak K, Pye RJ, Reece JF, Rojas Gutierrez J, Sadia H, Schmeling SK, Shamanova O, Sherlock AG, Stammnitz M, Steenland-Smit AE, Svitich A, Tapia Martínez LJ, Thoya Ngoka I, Torres CG, Tudor EM, van der Wel MG, Viţălaru BA, Vural SA, Walkinton O, Wang J, Wehrle-Martinez AS, Widdowson SA, Stratton MR, Alexandrov LB, Martincorena I, Murchison EP . Somatic evolution and global expansion of an ancient transmissible cancer lineage . Science . 365 . 6452 . eaau9923 . August 2019 . 31371581 . 7116271 . 10.1126/science.aau9923 .
  17. Belov K . The role of the Major Histocompatibility Complex in the spread of contagious cancers . Mammalian Genome . 22 . 1–2 . 83–90 . February 2011 . 20963591 . 10.1007/s00335-010-9294-2 . 8303843 .
  18. Siddle HV, Kreiss A, Eldridge MD, Noonan E, Clarke CJ, Pyecroft S, Woods GM, Belov K . Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial . Proceedings of the National Academy of Sciences of the United States of America . 104 . 41 . 16221–6 . October 2007 . 17911263 . 1999395 . 10.1073/pnas.0704580104 . free .
  19. Web site: Harrison C . Clonally transmissible cancers in nature. May 2018 . Cancer Therapy Advisor. en-US. 2019-10-03.
  20. Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA . Clonal origin and evolution of a transmissible cancer . Cell . 126 . 3 . 477–87 . August 2006 . 16901782 . 2593932 . 10.1016/j.cell.2006.05.051 .
  21. Copper HL, Mackay CM, Banfield WG . Chromosome studies of a contagious reticulum cell sarcoma of the Syrian hamster . Journal of the National Cancer Institute . 33 . 4 . 691–706 . October 1964 . 14220251 . 10.1093/jnci/33.4.691 .
  22. Banfield WG, Woke PA, Mackay CM, Cooper HL . Mosquito transmission of a reticulum cell sarcoma of hamsters . Science . 148 . 3674 . 1239–40 . May 1965 . 14280009 . 10.1126/science.148.3674.1239 . 1965Sci...148.1239B . 12611674 .
  23. Pearse AM, Swift K . Allograft theory: transmission of devil facial-tumour disease . Nature . 439 . 7076 . 549 . February 2006 . 16452970 . 10.1038/439549a . 2006Natur.439..549P . 4409863 . free .
  24. Epstein B, Jones M, Hamede R, Hendricks S, McCallum H, Murchison EP, Schönfeld B, Wiench C, Hohenlohe P, Storfer A . Rapid evolutionary response to a transmissible cancer in Tasmanian devils . Nature Communications . 7 . 1 . 12684 . August 2016 . 27575253 . 10.1038/ncomms12684 . 5013612 . 2016NatCo...712684E . free .
  25. Yong E . Ed Yong. 2015-04-09. Selfish shellfish cells cause contagious clam cancer. National Geographic. https://web.archive.org/web/20150905085758/http://phenomena.nationalgeographic.com/2015/04/09/selfish-shellfish-cells-cause-contagious-clam-cancer/. 2015-09-05. 2015-04-10.
  26. Metzger MJ, Reinisch C, Sherry J, Goff SP . Horizontal transmission of clonal cancer cells causes leukemia in soft-shell clams . Cell . 161 . 2 . 255–63 . April 2015 . 25860608 . 4393529 . 10.1016/j.cell.2015.02.042 .
  27. Metzger MJ, Villalba A, Carballal MJ, Iglesias D, Sherry J, Reinisch C, Muttray AF, Baldwin SA, Goff SP . Widespread transmission of independent cancer lineages within multiple bivalve species . Nature . 534 . 7609 . 705–9 . June 2016 . 27338791 . 4939143 . 10.1038/nature18599 . 2016Natur.534..705M .
  28. Frierman EM, Andrews JD . Occurrence of hematopoietic neoplasms in Virginia oysters (Crassostrea virginica) . Journal of the National Cancer Institute . 56 . 2 . 319–24 . February 1976 . 1255763 . 10.1093/jnci/56.2.319 .

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